Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 17/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590195 | 0.85 | PKM (0.64) | PKMBRAF | |
| SCHEMBL3602325 | 0.76 | BRAF (0.62) | PKMBRAFKMT2A | |
| SCHEMBL3590393 | 0.76 | BRAF (0.63) | PKMBRAF | |
| SCHEMBL14138556 | 0.76 | BRAF (0.73) | PKMBRAF | |
| SCHEMBL14138806 | 0.74 | BRAF (0.47) | PKMBRAF | |
| SCHEMBL14138586 | 0.74 | BRAF (0.51) | PKMBRAF | |
| SCHEMBL14138849 | 0.73 | BRAF (0.74) | PKMBRAF | |
| SCHEMBL3582074 | 0.73 | PKM (0.62) | PKMBRAF | |
| SCHEMBL14138566 | 0.72 | BRAF (0.73) | PKMBRAF | |
| SCHEMBL14138670 | 0.71 | BRAF (0.53) | PKMBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |