Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 4/20 | 0.37 |
| ▸ | ACACB | O00763 | 8/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL926275 | 0.90 | GPR119 (0.51) | GPR119KCNH2HCRTR2SMOMKNK1 | |
| SCHEMBL3623896 | 0.87 | GPR119 (0.41) | GPR119KCNH2HCRTR2SMOMKNK1 | |
| SCHEMBL3617071 | 0.87 | GPR119 (0.41) | GPR119KCNH2HCRTR2SMOACACB | |
| SCHEMBL10316045 | 0.87 | HCRTR2 (0.46) | GPR119KCNH2HCRTR2SMO | |
| SCHEMBL10316044 | 0.76 | GPR119 (0.48) | GPR119HCRTR2 | |
| SCHEMBL3622680 | 0.76 | GPR119 (0.53) | GPR119KCNH2HCRTR2SMO | |
| SCHEMBL3627148 | 0.74 | GPR119 (0.51) | GPR119KCNH2HCRTR2SMO | |
| SCHEMBL3486741 | 0.74 | KDM4E (0.47) | GPR119KCNH2ACACB | |
| SCHEMBL3625073 | 0.72 | KDM4E (0.45) | GPR119KCNH2ACACBABL1BCR | |
| SCHEMBL3486398 | 0.72 | GPR119 (0.58) | GPR119HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |