Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 19/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638755 | 0.90 | PKM (0.65) | PKMBRAF | |
| SCHEMBL3601321 | 0.89 | BRAF (0.57) | PKMBRAF | |
| SCHEMBL3587501 | 0.85 | PKM (0.66) | PKMBRAF | |
| SCHEMBL13167777 | 0.84 | PKM (0.63) | PKMBRAF | |
| SCHEMBL3594427 | 0.84 | BRAF (0.65) | PKMBRAF | |
| SCHEMBL3592923 | 0.84 | PKM (0.58) | PKMBRAF | |
| SCHEMBL3587261 | 0.83 | PKM (0.61) | PKMBRAF | |
| SCHEMBL3580076 | 0.83 | BRAF (0.51) | PKMBRAF | |
| SCHEMBL3580073 | 0.83 | BRAF (0.51) | PKMBRAF | |
| SCHEMBL3587257 | 0.83 | BRAF (0.64) | PKMBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |