Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COXFA4 | O00483 | 2/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.54 |
| ▸ | ODC1 | P11926 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 13/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14139181 | 0.89 | COXFA4 (0.65) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL12315552 | 0.85 | COXFA4 (0.74) | COXFA4HSP90AA1HIF1A | |
| SCHEMBL12315460 | 0.85 | COXFA4 (0.67) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL12315565 | 0.84 | COXFA4 (0.64) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL13535021 | 0.83 | COXFA4 (0.65) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL4432826 | 0.82 | COXFA4 (0.67) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL12315561 | 0.82 | COXFA4 (0.67) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL4432821 | 0.82 | COXFA4 (0.67) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL14139185 | 0.79 | COXFA4 (1.00) | COXFA4HSP90AA1ODC1HIF1AEPAS1 | |
| SCHEMBL3457885 | 0.78 | COXFA4 (0.56) | COXFA4HSP90AA1ODC1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410998-B2 | Inhibitors of NADH:ubiquinone oxidoreductase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-08-12 | — | — | US | disclosed |