COXFA4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL1095981	0.55	3/20
SCHEMBL4293165	0.55	3/20
SCHEMBL3345492	0.53	3/20
SCHEMBL3469406	0.53	3/20
SCHEMBL3470086	0.53	3/20
SCHEMBL4204071	0.52	3/20
SCHEMBL3345332	0.49	3/20
SCHEMBL3470070	0.49	3/20
SCHEMBL3470469	0.49	3/20
SCHEMBL3362802	0.44	3/20

Clinical trials — most relevant to COXFA4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patients	PHASE4	COMPLETED
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
A Pilot Clinical Trial With the Iron Chelator Deferiprone in Parkinson's Disease	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder	PHASE2	WITHDRAWN
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC	PHASE1/PHASE2	UNKNOWN
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease	EARLY_PHASE1	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Physical Activity Following Surgery Induced Weight Loss	nan	COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
DINAMITE Study Nutritional State and Effect Diet in Mitochondrial Disease	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Saturated Fat Versus Monounsaturated Fat and Insulin Action	nan	COMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
ACTIV- Exercise Intervention in Healthy Young Men	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a COXFA4 binder may also engage these)

Protein	Name	Similarity
Q0MQ99	—	1.000	Q0MQ99 →
Q0MQ98	—	1.000	Q0MQ98 →
Q0MQ97	—	1.000	Q0MQ97 →
Q4R542	—	0.998	Q4R542 →
Q3YAJ5	—	0.998	Q3YAJ5 →
Q6PBH5	—	0.995	Q6PBH5 →
Q62425	—	0.991	Q62425 →
Q01321	—	0.991	Q01321 →
Q4FZG9	—	0.988	Q4FZG9 →
Q3SZ44	—	0.986	Q3SZ44 →
COXFA4L2	Cytochrome c oxidase hypoxia associated subun	0.985	landscape →
Q9P0S2	—	0.969	Q9P0S2 →
G1QDE8	—	0.968	G1QDE8 →
Q9C002	—	0.968	Q9C002 →
Q96KF7	—	0.968	Q96KF7 →
Q5RK28	—	0.967	Q5RK28 →
Q78RX3	—	0.966	Q78RX3 →
Q5REX0	—	0.966	Q5REX0 →
Q9CQQ0	—	0.966	Q9CQQ0 →
Q69YU5	—	0.966	Q69YU5 →
Q8BTC1	—	0.965	Q8BTC1 →
Q96EX1	—	0.965	Q96EX1 →
D3Z7Q2	—	0.965	D3Z7Q2 →
Q8BTE5	—	0.964	Q8BTE5 →
E2R5I0	—	0.963	E2R5I0 →
P0DO45	—	0.963	P0DO45 →
D3ZAF6	—	0.963	D3ZAF6 →
A2VDV9	—	0.963	A2VDV9 →
Q5RCY6	—	0.963	Q5RCY6 →
A8MTT3	—	0.963	A8MTT3 →