Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5126112 | 0.86 | MAPT (0.52) | MAPTRAB9APOLBAKR1C3KDM4E | |
| SCHEMBL5126103 | 0.86 | MAPT (0.52) | MAPTRAB9APOLBAKR1C3KDM4E | |
| SCHEMBL12196254 | 0.84 | CTSS (0.48) | MAPTRAB9APOLBAKR1C3 | |
| SCHEMBL2162724 | 0.84 | CTSS (0.48) | MAPTRAB9APOLBAKR1C3 | |
| SCHEMBL12196232 | 0.84 | MAPT (0.47) | MAPTRAB9APOLBAKR1C3SMN1; SMN2 | |
| SCHEMBL2162730 | 0.84 | CTSS (0.48) | MAPTRAB9APOLBAKR1C3 | |
| SCHEMBL2162758 | 0.81 | MAPT (0.46) | MAPTRAB9APOLBMGLL | |
| SCHEMBL2162752 | 0.81 | MAPT (0.46) | MAPTRAB9APOLBMGLL | |
| SCHEMBL12400766 | 0.79 | MAPT (0.42) | MAPTRAB9APOLBKMT2AMGLL | |
| SCHEMBL1115881 | 0.76 | CYP1A2 (0.64) | RAB9APOLBAKR1C3KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744755-B1 | COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S INHIBITORS | IRM LLC (BM) | 2012-12-05 | — | — | EP | disclosed |