Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.61 |
| ▸ | SIK2 | Q9H0K1 | 12/20 | 0.59 |
| ▸ | SIK3 | Q9Y2K2 | 12/20 | 0.59 |
| ▸ | ABL1 | P00519 | 12/20 | 0.59 |
| ▸ | SIK1 | P57059 | 10/20 | 0.59 |
| ▸ | KIT | P10721 | 5/20 | 0.58 |
| ▸ | FLT3 | P36888 | 4/20 | 0.58 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.55 |
| ▸ | LYN | P07948 | 3/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | FYN | P06241 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | YES1 | P07947 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | HCK | P08631 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14141970 | 0.89 | SRC (0.58) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL14142048 | 0.89 | SRC (0.60) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL14141966 | 0.88 | SRC (0.48) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL14141953 | 0.86 | ABL1 (0.47) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL14142337 | 0.85 | SRC (0.46) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL14142339 | 0.84 | SRC (0.47) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL14142570 | 0.84 | SRC (0.53) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL14141818 | 0.84 | SRC (0.51) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL3536666 | 0.83 | ABL1 (0.75) | SRCSIK2SIK3ABL1SIK1 | |
| SCHEMBL30144989 | 0.83 | ABL1 (0.75) | SRCSIK2SIK3ABL1SIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532662-B1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | NANJING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD (CN) | 2016-01-27 | — | — | EP | claimed |
| US-9108954-B2 | Synthesis process of dasatinib and intermediate thereof | NAN JING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD. (CN) | 2015-08-18 | — | — | US | claimed |
| US-20130030177-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | Nan Jing Cavendish Bio-Engineering Technology Co. Ltd. (CN) | 2013-01-31 | — | — | US | claimed |
| EP-2532662-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | Nanjing Cavendish Bio-Engineering Technology Co., Ltd. (CN) | 2012-12-12 | — | — | EP | claimed |
| EP-2532662-B1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | NANJING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD (CN) | 2016-01-27 | — | — | EP | disclosed |
| US-9108954-B2 | Synthesis process of dasatinib and intermediate thereof | NAN JING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD. (CN) | 2015-08-18 | — | — | US | disclosed |
| US-20130030177-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | Nan Jing Cavendish Bio-Engineering Technology Co. Ltd. (CN) | 2013-01-31 | — | — | US | disclosed |
| EP-2532662-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | Nanjing Cavendish Bio-Engineering Technology Co., Ltd. (CN) | 2012-12-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030177-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | ABL1, YES1, ABL2 | SRC 8/4885SIK2 135/4885SIK3 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.