Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.75 |
| ▸ | SIK2 | Q9H0K1 | 12/20 | 0.75 |
| ▸ | SIK3 | Q9Y2K2 | 12/20 | 0.75 |
| ▸ | SIK1 | P57059 | 10/20 | 0.75 |
| ▸ | SRC | P12931 | 6/20 | 0.72 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.70 |
| ▸ | KIT | P10721 | 4/20 | 0.68 |
| ▸ | BCR | P11274 | 3/20 | 0.68 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | LCK | P06239 | 2/20 | 0.68 |
| ▸ | FYN | P06241 | 2/20 | 0.68 |
| ▸ | CSF1R | P07333 | 2/20 | 0.68 |
| ▸ | YES1 | P07947 | 2/20 | 0.68 |
| ▸ | LYN | P07948 | 2/20 | 0.68 |
| ▸ | RET | P07949 | 2/20 | 0.68 |
| ▸ | HCK | P08631 | 2/20 | 0.68 |
| ▸ | BRAF | P15056 | 2/20 | 0.68 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536666 | 1.00 | ABL1 (0.75) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL14141736 | 0.93 | ABL1 (0.73) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL14665835 | 0.92 | ABL1 (0.64) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL3396435 | 0.91 | ABL1 (0.73) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL12438117 | 0.91 | ABL1 (0.73) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL29885048 | 0.91 | ABL1 (0.73) | ABL1SIK2SIK3SIK1SRC | |
| Water SCHEMBL3226546 | 0.90 | ABL1 (0.72) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL18971581 | 0.90 | ABL1 (0.72) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL4252892 | 0.90 | ABL1 (0.69) | ABL1SIK2SIK3SIK1SRC | |
| SCHEMBL4257532 | 0.89 | SIK2 (0.67) | ABL1SIK2SIK3SIK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113727981-B | Kinase inhibitor, preparation, pharmaceutical composition and application thereof | 湖南华纳大药厂股份有限公司 | 2023-01-20 | — | — | CN | disclosed |