Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27844997 | 0.91 | BRAF (0.57) | BRAFMAPK14CA9KDR | |
| SCHEMBL14147199 | 0.89 | BRAF (0.55) | BRAFMAPK14KDRMAPT | |
| SCHEMBL27862197 | 0.89 | BRAF (0.55) | BRAFMAPK14KDR | |
| SCHEMBL27844947 | 0.87 | BRAF (0.53) | BRAFMAPK14KDRMAPT | |
| SCHEMBL27862530 | 0.87 | BRAF (0.54) | BRAFMAPK14CA9KDR | |
| SCHEMBL27862196 | 0.86 | BRAF (0.55) | BRAFMAPK14RAF1KDR | |
| SCHEMBL27862284 | 0.86 | BRAF (0.53) | BRAFMAPK14SMN1; SMN2MAPT | |
| SCHEMBL27845008 | 0.86 | BRAF (0.51) | BRAFMAPK14KDRMAPT | |
| SCHEMBL14146769 | 0.85 | BRAF (0.60) | BRAFMAPK14RAF1MTORPIK3CA | |
| SCHEMBL28796317 | 0.85 | BRAF (0.53) | BRAFMAPK14CA9KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012159557-A1 | SUBSTITUTED TRIAZINE PHENYLUREA DERIVATIVE AND USE THEREOF AGAINST TUMORS | 浙江海正药业股份有限公司 (CN) | 2012-11-29 | — | — | WO | disclosed |