Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14151601 | 1.00 | MAP2K1 (0.36) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL14151630 | 0.85 | MAP2K1 (0.44) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL14241152 | 0.85 | MAP2K1 (0.44) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL14151627 | 0.85 | MAP2K1 (0.44) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL14167577 | 0.77 | MAP2K1 (0.35) | MAP2K1 | |
| SCHEMBL14151740 | 0.74 | — | — | |
| SCHEMBL14151741 | 0.74 | — | — | |
| SCHEMBL14226939 | 0.72 | — | — | |
| SCHEMBL14226940 | 0.72 | — | — | |
| SCHEMBL14241607 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718276-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES | Novartis AG (CH) | 2014-04-16 | — | — | EP | claimed |
| US-8470878-B2 | Heterocyclic sulfonamide derivatives | NOVARTIS AG (CH) | 2013-06-25 | — | — | US | claimed |
| WO-2012168884-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2012-12-13 | — | — | WO | claimed |
| US-20120316149-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-12-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316149-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES | BRAF, MAP3K8, MAP3K2 | MAP2K1 74/4885CHEK1 284/4885MAP2K2 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.