Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17117049 | 0.87 | EGLN2 (0.49) | EGLN2MAP4K4CTSACHEK1CYP11B2 | |
| SCHEMBL12496522 | 0.82 | CHEK1 (0.49) | EGLN2CHEK1CYP11B2KDM4EHPGD | |
| SCHEMBL13681290 | 0.81 | TNF (0.49) | EGLN2MAP4K4CTSACHEK1ADORA2A | |
| SCHEMBL18461760 | 0.81 | EGLN2 (0.44) | EGLN2MAP4K4CTSACHEK1ADORA2A | |
| SCHEMBL6241092 | 0.81 | CTSS (0.58) | CYP11B2KDM4EDGAT1CYP11B1 | |
| SCHEMBL70602 | 0.80 | CHEK1 (0.63) | GABRG2GABRB3GABRA5GABRA3EGLN2 | |
| SCHEMBL31588411 | 0.80 | CHEK1 (0.63) | GABRG2GABRB3GABRA5GABRA3EGLN2 | |
| SCHEMBL12630708 | 0.79 | CHEK1 (0.51) | EGLN2CTSACHEK1CYP11B2DGAT1 | |
| SCHEMBL18462125 | 0.79 | CHEK1 (0.44) | GABRG2GABRB3GABRA5GABRA3EGLN2 | |
| SCHEMBL16675750 | 0.78 | CHEK1 (0.60) | EGLN2CTSACHEK1CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162635-A1 | METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2012-11-29 | — | — | WO | disclosed |