Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | CSK | P41240 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 19/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14154221 | 0.93 | AURKB (0.59) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL14154111 | 0.87 | AURKB (0.51) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL14154263 | 0.83 | AURKA (0.53) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL13248919 | 0.77 | AURKB (0.77) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL5045154 | 0.76 | AURKB (1.00) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL31060166 | 0.76 | AURKB (1.00) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL14154178 | 0.76 | AURKA (0.51) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL1735772 | 0.75 | AURKB (0.70) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL1734663 | 0.75 | AURKB (0.73) | AURKBEGFRIGF1RFGFR1SRC | |
| SCHEMBL5048903 | 0.74 | AURKB (0.80) | AURKBEGFRIGF1RFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402582-B2 | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-22 | — | — | US | disclosed |