Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CSK | P41240 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14154221 | 0.89 | AURKB (0.59) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL14154178 | 0.87 | AURKA (0.51) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL14154111 | 0.83 | AURKB (0.51) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL14154159 | 0.83 | AURKB (0.61) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL1734683 | 0.78 | AURKA (0.63) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL1733758 | 0.76 | AURKA (0.62) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5048641 | 0.75 | AURKA (0.87) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL1733812 | 0.74 | AURKA (0.64) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL14154138 | 0.73 | ALDH1A1 (0.35) | AURKAAURKBKDREGFRCSK | |
| SCHEMBL6530607 | 0.69 | AURKA (0.74) | AURKAAURKBKDREGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402582-B2 | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-22 | — | — | US | disclosed |