Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14155125 | 0.81 | KMO (0.46) | CYP11B1CYP11B2SMN1; SMN2KMT2AKMO | |
| SCHEMBL14155126 | 0.81 | CYP11B1 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL19738739 | 0.78 | RECQL (0.42) | CYP11B1CYP11B2NPC1RAB9ARECQL | |
| SCHEMBL19684424 | 0.75 | SLC6A2 (0.40) | CYP11B1CYP11B2NPC1RAB9ARECQL | |
| SCHEMBL10050859 | 0.73 | RECQL (0.43) | CYP11B1CYP11B2NPC1RAB9ARECQL | |
| SCHEMBL30449976 | 0.73 | RECQL (0.43) | CYP11B1CYP11B2NPC1RAB9ARECQL | |
| SCHEMBL28172026 | 0.72 | CYP11B1 (0.42) | CYP11B1CYP11B2NPC1RAB9ARECQL | |
| SCHEMBL22559859 | 0.69 | RECQL (0.40) | CYP11B1CYP11B2NPC1RAB9ARECQL | |
| SCHEMBL5305834 | 0.68 | CYP11B1 (0.43) | CYP11B1CYP11B2NPC1RAB9ARECQL | |
| SCHEMBL29520927 | 0.67 | RECQL (0.43) | CYP11B1CYP11B2RAB9ARECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827427-B1 | ARYLOXYETHYLAMINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION | SOLVAY PHARM BV (NL) | 2008-07-23 | — | — | EP | disclosed |