Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4836832 | 0.99 | CHRM1 (0.41) | CHRM1HRH1PAK1TP53MPL | |
| SCHEMBL14156596 | 0.90 | TP53 (0.41) | CHRM1HRH1PAK1TP53MPL | |
| Hydrochloric Acid SCHEMBL4837164 | 0.89 | TP53 (0.40) | CHRM1HRH1PAK1TP53MPL | |
| SCHEMBL14156601 | 0.86 | MPL (0.39) | CHRM1MPLBACE1 | |
| SCHEMBL14156616 | 0.85 | DRD2 (0.40) | CHRM1HRH1MPLDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL4845753 | 0.85 | MPL (0.38) | CHRM1MPLBACE1 | |
| SCHEMBL4842627 | 0.84 | TP53 (0.43) | CHRM1TP53DRD2BACE1MAPT | |
| Hydrochloric Acid SCHEMBL4837078 | 0.84 | DRD2 (0.39) | CHRM1HRH1MPLDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL4835541 | 0.83 | TP53 (0.42) | CHRM1TP53DRD2BACE1MAPT | |
| SCHEMBL14156619 | 0.80 | DRD2 (0.49) | CHRM1HRH1PAK1DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| US-7214673-B2 | For therapy of psychosis and bipolar disorder | ELI LILLY AND COMPANY (US) | 2007-05-08 | — | — | US | disclosed |