Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4844260 | 0.99 | DRD2 (0.41) | DRD2DRD3CHRM1DRD4DRD1 | |
| Hydrochloric Acid SCHEMBL4844246 | 0.99 | DRD2 (0.41) | DRD2DRD3CHRM1DRD4DRD1 | |
| SCHEMBL14156755 | 0.95 | DRD2 (0.43) | DRD2DRD3CHRM1DRD4DRD1 | |
| Hydrochloric Acid SCHEMBL4836852 | 0.94 | DRD2 (0.42) | DRD2DRD3CHRM1DRD4DRD1 | |
| Hydrochloric Acid SCHEMBL4836864 | 0.94 | DRD2 (0.42) | DRD2DRD3CHRM1DRD4DRD1 | |
| SCHEMBL14156733 | 0.90 | CHRM1 (0.48) | DRD2DRD3CHRM1DRD4DRD1 | |
| SCHEMBL14156741 | 0.87 | CHRM1 (0.38) | DRD2DRD3CHRM1DRD4DRD1 | |
| SCHEMBL4836502 | 0.85 | DRD2 (0.46) | DRD2DRD3CHRM1DRD4DRD1 | |
| SCHEMBL4836497 | 0.85 | DRD2 (0.46) | DRD2DRD3CHRM1DRD4DRD1 | |
| SCHEMBL6207006 | 0.84 | CHRM1 (0.49) | DRD2DRD3CHRM1DRD4DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1546134-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | LILLY CO ELI (US) | 2007-05-02 | — | — | EP | disclosed |