SCHEMBL14158181

SCHEMBL14158181

C=CCn1cc(C(O)(c2ccc3c(cnn3-c3ccc(F)cc3)c2)C(F)(F)F)cc1C(=O)NCN

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 16/20 0.57
SMO Q99835 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3011846 0.93 NR3C1 (0.56) NR3C1SMO
SCHEMBL3014673 0.91 NR3C1 (0.59) NR3C1SMO
SCHEMBL3006260 0.90 NR3C1 (0.54) NR3C1SMO
SCHEMBL3018350 0.90 NR3C1 (0.62) NR3C1SMO
SCHEMBL3016202 0.89 NR3C1 (0.63) NR3C1SMO
SCHEMBL3011848 0.86 NR3C1 (0.55) NR3C1SMO
SCHEMBL3000307 0.86 NR3C1 (0.59) NR3C1SMO
SCHEMBL2999977 0.84 NR3C1 (0.57) NR3C1SMO
SCHEMBL14157971 0.84 NR3C1 (0.66) NR3C1
SCHEMBL3012630 0.82 NR3C1 (0.54) NR3C1SMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008070507-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-06-12 WO disclosed