Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYBB | P04839 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | EIF2AK3 | Q9NZJ5 | 17/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14158938 | 0.87 | CYBB (0.62) | CYBBNOTUMRIPK1 | |
| SCHEMBL14242757 | 0.86 | CYBB (0.47) | CYBBNOTUMEIF2AK3EIF2AK2EIF2AK1 | |
| SCHEMBL14158597 | 0.86 | CYBB (0.47) | CYBBNOTUMEIF2AK3EIF2AK4EIF2AK2 | |
| SCHEMBL14158616 | 0.82 | CYP11B1 (0.39) | CYBBNOTUMEIF2AK3 | |
| SCHEMBL14158815 | 0.81 | CYBB (0.46) | CYBBNOTUMEIF2AK3EIF2AK4 | |
| SCHEMBL15753905 | 0.80 | CYBB (0.62) | CYBBNOTUMEIF2AK3 | |
| SCHEMBL14243353 | 0.80 | EIF2AK3 (0.33) | CYBBEIF2AK3RIPK1 | |
| SCHEMBL14158613 | 0.78 | NOTUM (0.39) | CYBBNOTUM | |
| SCHEMBL14158638 | 0.77 | CYBB (0.58) | CYBBNOTUMEIF2AK3 | |
| SCHEMBL15754133 | 0.76 | CYBB (0.67) | CYBBEIF2AK3EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877742-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2014-11-04 | — | — | US | disclosed |
| US-8877742-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2014-11-04 | — | — | US | disclosed |
| US-8877742-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2014-11-04 | — | — | US | disclosed |
| US-20140155375-A1 | NOVEL COMPOUNDS | GlaxoSmithKline Interllectual Property Limited (GB) | 2014-06-05 | — | — | US | disclosed |
| US-20140155375-A1 | NOVEL COMPOUNDS | GlaxoSmithKline Interllectual Property Limited (GB) | 2014-06-05 | — | — | US | disclosed |
| US-20140155375-A1 | NOVEL COMPOUNDS | GlaxoSmithKline Interllectual Property Limited (GB) | 2014-06-05 | — | — | US | disclosed |
| EP-2717694-A1 | NOVEL COMPOUNDS | GlaxoSmithKline Intellectual Property Limited (GB) | 2014-04-16 | — | — | EP | disclosed |
| WO-2012170752-A1 | NOVEL COMPOUNDS | GLAXO WELLCOME MANUFACTURING PTE LTD (SG) | 2012-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155375-A1 | NOVEL COMPOUNDS | CYBB, NOX1, NOX4 | CYBB 1/4885NOTUM 2865/4885EIF2AK3 3658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.