Sugi Predict

Sugi Predict / Targets / NOX4

NOX4

NADPH oxidase 4 · Q9NPH5 · NOX4 on Sugi Atlas →

14,155 patent compounds predicted against NOX4, 9,374 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1302350 SCHEMBL1302350 1.00 20/20
SCHEMBL1302601 SCHEMBL1302601 1.00 20/20
Setanaxib Setanaxib (SCHEMBL1302603) 1.00 20/20
SCHEMBL1302618 SCHEMBL1302618 1.00 20/20
SCHEMBL1302623 SCHEMBL1302623 1.00 20/20
SCHEMBL1302916 SCHEMBL1302916 1.00 20/20
SCHEMBL1303017 SCHEMBL1303017 1.00 20/20
SCHEMBL1303067 SCHEMBL1303067 0.82 20/20
SCHEMBL1302610 SCHEMBL1302610 0.81 20/20
SCHEMBL1302200 SCHEMBL1302200 0.74 20/20
SCHEMBL1302723 SCHEMBL1302723 0.73 20/20
SCHEMBL1302967 SCHEMBL1302967 0.73 20/20
SCHEMBL1302943 SCHEMBL1302943 0.72 20/20
SCHEMBL1302270 SCHEMBL1302270 0.67 20/20
SCHEMBL1302563 SCHEMBL1302563 0.67 20/20
SCHEMBL1303051 SCHEMBL1303051 0.66 20/20
SCHEMBL1302583 SCHEMBL1302583 0.65 20/20
SCHEMBL1302062 SCHEMBL1302062 0.63 20/20
SCHEMBL1302879 SCHEMBL1302879 0.61 20/20
SCHEMBL1303061 SCHEMBL1303061 0.61 20/20

Clinical trials — most relevant to NOX4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes PHASE4UNKNOWN
Cardiotoxicity in Breast Cancer Patients PHASE4RECRUITING
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE PHASE2UNKNOWN
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing. PHASE1/PHASE2COMPLETED
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS PHASE2RECRUITING
Salt-Sensitivity and Immunity Cell Activation PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Effect of Polyphenols on Peripheral Vascular Disease. PHASE1/PHASE2COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease PHASE2COMPLETED
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers PHASE1COMPLETED
Novel Approaches for Improving Vascular Function in Veterans With HFpEF PHASE1RECRUITING
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction PHASE1COMPLETED
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM PHASE1WITHDRAWN
Effect of IFN-γ on Innate Immune Cells PHASE1COMPLETED
A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus PHASE1COMPLETED
Role of NADPH Oxidase in Microvascular Dysfunction Following GDM EARLY_PHASE1RECRUITING
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women EARLY_PHASE1COMPLETED
Covid-19: Possible Role of Neutrophil Extracellular Traps nanUNKNOWN
Role of Nox2 in CNI-induced Renal Fibrosis nanCOMPLETED
Early Regenerative Intervention for Post-Traumatic Osteoarthritis nanUNKNOWN
Role of ROS and cAMP-PKA Biomarkers in ADPKD nanACTIVE_NOT_RECRUITING
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19 nanCOMPLETED
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
NOX4 and Related Biomarkers in ADPKD nanRECRUITING
Mechanisms for Individual Differences in Hypertension in Obstructive Sleep nanCOMPLETED
Flow Mediated Dilation in Association With Hyperuricemia nanUNKNOWN
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure nanUNKNOWN
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage nanCOMPLETED
Anti-inflammatory Effects of Fiber nanCOMPLETED
High Altitude Medical Research Expedition Himlung 2013 - a Study of Human Adaption to Hypoxia nanCOMPLETED
Oxidative Stress and Haemostasis Abnormalities in Cirrhosis nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NOX4 binder may also engage these)

ProteinNameSimilarity
Q5R5C5 — 1.000 Q5R5C5 →
Q924V1 — 1.000 Q924V1 →
Q9JHI8 — 1.000 Q9JHI8 →
Q672J9 — 0.982 Q672J9 →
Q9SUT8 — 0.982 Q9SUT8 →
Q6INU7 — 0.981 Q6INU7 →
Q672K1 — 0.981 Q672K1 →
Q9XYS3 — 0.980 Q9XYS3 →
F1Q8R9 — 0.979 F1Q8R9 →
Q9FJD6 — 0.979 Q9FJD6 →
Q9LZU9 — 0.978 Q9LZU9 →
O81211 — 0.978 O81211 →
Q8K385 — 0.978 Q8K385 →
O81209 — 0.977 O81209 →
Q96PB1 — 0.976 Q96PB1 →
E9PX95 — 0.976 E9PX95 →
A2VE04 — 0.976 A2VE04 →
Q6IWY1 — 0.975 Q6IWY1 →
Q6IPT4 — 0.975 Q6IPT4 →
Q7TN73 — 0.975 Q7TN73 →
Q2TV84 — 0.975 Q2TV84 →
Q9GL50 — 0.975 Q9GL50 →
Q7Z3F1 — 0.975 Q7Z3F1 →
NOX3 NADPH oxidase 3 0.975 landscape →
Q56A06 — 0.975 Q56A06 →
G5ECB2 — 0.975 G5ECB2 →
Q8VY13 — 0.975 Q8VY13 →
Q6ZNA5 — 0.975 Q6ZNA5 →
Q8R420 — 0.975 Q8R420 →
Q9SW17 — 0.974 Q9SW17 →