SCHEMBL14159243

SCHEMBL14159243

CCCOc1ccc(-c2ccccc2OC)cc1C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 3/20 0.47
CCND1 P24385 3/20 0.47
HDAC3 O15379 5/20 0.47
HDAC1 Q13547 5/20 0.47
HDAC2 Q92769 5/20 0.47
HDAC6 Q9UBN7 4/20 0.47
HDAC4 P56524 3/20 0.47
HDAC7 Q8WUI4 3/20 0.47
HDAC10 Q969S8 3/20 0.47
HDAC11 Q96DB2 3/20 0.47
HDAC8 Q9BY41 3/20 0.47
HDAC9 Q9UKV0 3/20 0.47
HDAC5 Q9UQL6 3/20 0.47
ICMT O60725 1/20 0.47
KMT2A Q03164 5/20 0.46
MEN1 O00255 3/20 0.46
MAPT P10636 2/20 0.46
HPGD P15428 2/20 0.46
ALDH1A1 P00352 1/20 0.46
THRB P10828 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14557660 0.93 HDAC3 (0.47) CDK4CCND1HDAC3HDAC1HDAC2
SCHEMBL14564883 0.93 HDAC3 (0.47) CDK4CCND1HDAC3HDAC1HDAC2
SCHEMBL5149380 0.92 KMT2A (0.53) HDAC3HDAC1HDAC2HDAC6HDAC4
SCHEMBL4603062 0.90 ROCK2 (0.48) CDK4CCND1HDAC3HDAC1HDAC2
SCHEMBL14564885 0.90 ROCK2 (0.48) CDK4CCND1HDAC3HDAC1HDAC2
SCHEMBL14557920 0.90 ROCK2 (0.48) CDK4CCND1HDAC3HDAC1HDAC2
SCHEMBL5149313 0.89 KMT2A (0.48) HDAC3HDAC1HDAC2HDAC6HDAC4
SCHEMBL14557638 0.89 CDK4 (0.50) CDK4CCND1HDAC3HDAC1HDAC2
SCHEMBL14159167 0.89 MAPT (0.47) CDK4CCND1HDAC3HDAC1HDAC2
SCHEMBL14557606 0.89 ITGB2 (0.47) CDK4CCND1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1932831-A1 1,2-Diarylacetylene Derivatives of Acyltryptophanols Bayer Schering Pharma Aktiengesellschaft (DE) 2008-06-18 EP disclosed