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SCHEMBL14159649

SCHEMBL14159649

Cn1c(C(=O)NC2C3CC4CC2CC(C(N)=O)(C4)C3)ccc1-c1ccc(C(F)(F)CF)cc1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 20/20 0.45
▸ HSD11B2 P80365 5/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15706812 0.91 HSD11B1 (0.52) HSD11B1HSD11B2
SCHEMBL14157643 0.91 HSD11B1 (0.52) HSD11B1HSD11B2
SCHEMBL14159650 0.86 HSD11B1 (0.44) HSD11B1HSD11B2
SCHEMBL15706766 0.86 HSD11B1 (0.52) HSD11B1HSD11B2
SCHEMBL14157726 0.86 HSD11B1 (0.52) HSD11B1HSD11B2
SCHEMBL15706740 0.84 HSD11B1 (0.56) HSD11B1HSD11B2
SCHEMBL15667735 0.84 HSD11B1 (0.56) HSD11B1HSD11B2
SCHEMBL15666804 0.83 HSD11B1 (0.54) HSD11B1HSD11B2
SCHEMBL15706773 0.83 HSD11B1 (0.54) HSD11B1HSD11B2
SCHEMBL14157727 0.78 HSD11B1 (0.54) HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2699560-A2 5-CARBAMOYL-ADAMANTAN-2-YL AMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND PREPARATION PROCESS THEREOF SK Biopharmaceuticals Co., Ltd. (KR) 2014-02-26 — — EP disclosed
WO-2012169863-A2 5-CARBAMOYL-ADAMANTAN-2-YL AMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND PREPARATION PROCESS THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2012-12-13 — — WO disclosed
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