Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 16/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FECH | P22830 | 1/20 | 0.46 |
| ▸ | DCK | P27707 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14160547 | 0.77 | AURKA (0.69) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL13969679 | 0.76 | BRAF (0.55) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL4313520 | 0.73 | AURKA (0.76) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL4218373 | 0.72 | BRAF (0.68) | AURKAAURKBCYP2D6CYP2C9CSNK1D | |
| SCHEMBL13969680 | 0.71 | BRAF (0.51) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL4311285 | 0.70 | AURKA (0.75) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL4220074 | 0.70 | BRAF (0.75) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL4316892 | 0.68 | AURKA (0.74) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL4305091 | 0.67 | AURKA (0.76) | AURKAAURKBPLK4CITEPHB6 | |
| SCHEMBL4213079 | 0.66 | BRAF (0.55) | AURKAAURKBPLK4CITEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067119-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-05 | — | — | WO | disclosed |