Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17656739 | 0.93 | ALDH1A1 (0.55) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL10281036 | 0.84 | MAPT (0.47) | CNR2ALDH1A1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL19341535 | 0.84 | MAPT (0.51) | CNR2ALDH1A1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL14167598 | 0.81 | AKR1C3 (0.63) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL2744078 | 0.81 | CNR2 (0.53) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL13724949 | 0.81 | ALDH1A1 (0.57) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL18307176 | 0.81 | CNR2 (0.53) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL14642619 | 0.77 | CYP11B1 (0.55) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL13658041 | 0.77 | ALDH1A1 (0.50) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL14167546 | 0.77 | CNR2 (0.53) | CNR2ALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718293-A1 | SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS | Hutchison Medipharma Limited (CN) | 2014-04-16 | — | — | EP | disclosed |
| WO-2012167733-A1 | SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-12-13 | — | — | WO | disclosed |