Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Aminodiphenylmethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.49 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminodiphenylmethane SCHEMBL23925166 | 1.00 | GSR (0.67) | GSRPOLBKMT2ATDP1DPP8 | |
| Phenylglycine SCHEMBL23629659 | 0.89 | GSR (0.65) | GSRPOLBKMT2ATDP1DPP8 | |
| Diphenylacetic Acid SCHEMBL10358556 | 0.89 | GSR (0.65) | GSRPOLBKMT2ATDP1DPP8 | |
| Mandelic Acid SCHEMBL21383946 | 0.87 | GSR (0.62) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL29438093 | 0.86 | GSR (0.61) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL28214073 | 0.86 | GSR (0.91) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL28249816 | 0.85 | GSR (0.69) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL28249818 | 0.85 | GSR (0.69) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL3907035 | 0.83 | GSR (0.67) | GSRPOLBKMT2ATDP1DPP8 | |
| Phthalic Acid SCHEMBL19210210 | 0.83 | GSR (0.67) | GSRPOLBKMT2ATDP1DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210100910-A1 | MACROMOLECULES | STARPHARMA PTY LTD. (AU) | 2021-04-08 | — | — | US | disclosed |
| EP-2729179-B1 | MACROMOLECULES | STARPHARMA PTY LTD (AU) | 2020-09-23 | — | — | EP | disclosed |
| US-10265409-B2 | Macromolecules | STARPHARMA PTY LTD (AU) | 2019-04-23 | — | — | US | disclosed |
| US-20180326081-A1 | MACROMOLECULES | STARPHARMA PTY LTD. (AU) | 2018-11-15 | — | — | US | disclosed |
| US-20170354739-A1 | MACROMOLECULES | STARPHARMA PTY LTD (AU) | 2017-12-14 | — | — | US | disclosed |
| US-9744246-B2 | Macromolecules | STARPHARMA PTY LTD (AU) | 2017-08-29 | — | — | US | disclosed |
| US-20160220689-A1 | MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES | STARPHARMA PTY LTD. (AU) | 2016-08-04 | — | — | US | disclosed |
| WO-2015035446-A1 | MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES | STARPHARMA PTY LTD (AU) | 2015-03-19 | — | — | WO | disclosed |
| US-20140171375-A1 | MACROMOLECULES | STARPHARMA PTY LTD (AU) | 2014-06-19 | — | — | US | disclosed |
| EP-2729179-A1 | MACROMOLECULES | Starpharma Pty Ltd (AU) | 2014-05-14 | — | — | EP | disclosed |
| WO-2012167309-A1 | MACROMOLECULES | STARPHARMA PTY LTD (AU) | 2012-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10265409-B2 | Macromolecules | TUBA1C, DCTD, DTYMK | PTGS1 2326/4885GSR 2301/4885POLB 1475/4885 |
| US-20140171375-A1 | MACROMOLECULES | CD44, ADM2, EPCAM | PTGS1 2343/4885GSR 2620/4885POLB 1099/4885 |
| US-20170354739-A1 | MACROMOLECULES | TUBA1C, DCTD, DTYMK | PTGS1 2326/4885GSR 2301/4885POLB 1475/4885 |
| US-20160220689-A1 | MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES | CD44, FOLR1, FOLH1 | PTGS1 2325/4885GSR 1705/4885POLB 536/4885 |
| US-20210100910-A1 | MACROMOLECULES | BRDT, CD44, EPCAM | PTGS1 4136/4885GSR 732/4885POLB 444/4885 |
| US-20180326081-A1 | MACROMOLECULES | BRDT, CD44, EPCAM | PTGS1 4136/4885GSR 732/4885POLB 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.