Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Diphenylacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminodiphenylmethane SCHEMBL23925166 | 0.89 | GSR (0.67) | GSRPOLBKMT2ATDP1DPP8 | |
| Aminodiphenylmethane SCHEMBL14167635 | 0.89 | GSR (0.67) | GSRPOLBKMT2ATDP1DPP8 | |
| Phenylglycine SCHEMBL23629659 | 0.87 | GSR (0.65) | GSRPOLBKMT2ATDP1DPP8 | |
| Mandelic Acid SCHEMBL21383946 | 0.86 | GSR (0.62) | GSRPOLBKMT2ATDP1DPP8 | |
| Diphenamide SCHEMBL20572456 | 0.86 | GSR (0.54) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL29438093 | 0.84 | GSR (0.61) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL28214073 | 0.84 | GSR (0.91) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL28249818 | 0.83 | GSR (0.69) | GSRPOLBKMT2ATDP1DPP8 | |
| Lysine SCHEMBL28249816 | 0.83 | GSR (0.69) | GSRPOLBKMT2ATDP1DPP8 | |
| Diphenylamine SCHEMBL593267 | 0.82 | GSR (0.67) | GSRPOLBKMT2ATDP1DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261565-B1 | LYSINE SALT OF 4-DIPHENYLACETIC ACID AND ITS OPHTHALMIC FORMULATIONS | S.I.F.I. Società Industria Farmaceutica Italiana S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| US-4797423-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | S.I.F.I. SOCIETA INDUSTRIA FARMACEUTICA ITALIANA S.P.A. (IT) | 1989-01-10 | — | — | US | disclosed |
| EP-0261565-A1 | Lysine salt of 4-diphenylacetic acid and its ophthalmic formulations | S.I.F.I. Società Industria Farmaceutica Italiana S.p.A. (IT) | 1988-03-30 | — | — | EP | disclosed |