Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 11/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285879 | 0.84 | HIF1A (0.40) | HIF1APDE4APDE4BPDE4DPDE4C | |
| SCHEMBL14168853 | 0.83 | PDE4A (0.41) | HIF1APDE4APDE4BPDE4DPDE4C | |
| SCHEMBL9989172 | 0.82 | APP (0.45) | HIF1APDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8285881 | 0.82 | PDE4A (0.59) | HIF1APDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7317892 | 0.82 | PDE4A (0.59) | HIF1APDE4APDE4BPDE4DPDE4C | |
| SCHEMBL12094255 | 0.79 | APP (0.43) | HIF1APDE4APDE4BPDE4DPDE4C | |
| Hydrochloric Acid SCHEMBL22723238 | 0.78 | APP (0.42) | HIF1APDE4APDE4BPDE4DCSNK2A1 | |
| Hydrochloric Acid SCHEMBL22723239 | 0.78 | APP (0.42) | HIF1APDE4APDE4BPDE4DCSNK2A1 | |
| SCHEMBL15934281 | 0.78 | CSNK2A1 (0.43) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| SCHEMBL26984500 | 0.76 | CSNK2A1 (0.44) | PDE4APDE4BPDE4DPDE4CCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132536-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED | 2008-06-05 | — | — | US | disclosed |
| US-20080132536-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED | 2008-06-05 | — | — | US | disclosed |
| US-20070111995-A1 | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors | GLAXO GROUP LIMITED (GB) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132536-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4C | HIF1A 1944/4885PDE4A 1/4885PDE4B 2/4885 |
| US-20070111995-A1 | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors | PDE4B, PDE3B, PDE4A | HIF1A 3794/4885PDE4A 3/4885PDE4B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.