Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 3/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 3/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 9/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12094255 | 0.88 | APP (0.43) | APPPDE4APTGS1PTGS2PDE4D | |
| Hydrochloric Acid SCHEMBL22723238 | 0.87 | APP (0.42) | APPPDE4APTGS1PTGS2PDE4D | |
| Hydrochloric Acid SCHEMBL22723239 | 0.87 | APP (0.42) | APPPDE4APTGS1PTGS2PDE4D | |
| SCHEMBL14168853 | 0.83 | PDE4A (0.41) | PDE4APDE4DPDE4BPDE4CHIF1A | |
| SCHEMBL8285881 | 0.82 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4CHIF1A | |
| SCHEMBL14168917 | 0.82 | HIF1A (0.42) | APPPDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7317892 | 0.82 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4CHIF1A | |
| SCHEMBL14268228 | 0.81 | ACACB (0.39) | APPPDE4A | |
| SCHEMBL13419191 | 0.78 | SYK (0.47) | PDE4APDE4DPDE4BPDE4CCSNK2A1 | |
| SCHEMBL622131 | 0.78 | CSNK2A1 (0.43) | PDE4APTGS1PTGS2PDE4DPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966156-B1 | NEW COMPOUNDS III | ASTRAZENECA AB (SE) | 2011-12-21 | — | — | EP | disclosed |