Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14169732 | 0.88 | SLC6A2 (0.49) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL14169734 | 0.84 | SLC6A4 (0.69) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL4623844 | 0.84 | CYP2D6 (0.42) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL9347338 | 0.82 | SLC6A4 (0.53) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL9347734 | 0.82 | SLC6A4 (0.53) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL7996118 | 0.81 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL2208714 | 0.81 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL2211203 | 0.81 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL6696040 | 0.81 | SLC6A4 (0.49) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 | |
| SCHEMBL5659467 | 0.81 | SLC6A4 (0.49) | SLC6A2SLC6A4CYP2D6NOS2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384983-B2 | Inhibitor of monoamine uptake | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |