Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385701 | 0.92 | MAPK14 (0.49) | MAPK14MAPK11KMT2ABTKDRD4 | |
| SCHEMBL1382984 | 0.91 | MAPK14 (0.53) | MAPK14MAPK11RIPK2ALDH1A1 | |
| SCHEMBL1417039 | 0.87 | MAPK14 (0.63) | MAPK14MAPK11 | |
| SCHEMBL1386501 | 0.85 | MAPK14 (0.48) | MAPK14MAPK11KMT2ABTK | |
| SCHEMBL1384370 | 0.84 | MAPK14 (0.52) | MAPK14MAPK11KMT2ADRD4ALDH1A1 | |
| SCHEMBL1417180 | 0.83 | MAPK14 (0.56) | MAPK14MAPK11 | |
| SCHEMBL1416912 | 0.83 | MAPK14 (0.50) | MAPK14MAPK11 | |
| SCHEMBL1417219 | 0.82 | HPGD (0.54) | MAPK14MAPK11RIPK2 | |
| SCHEMBL5794081 | 0.82 | MAPK14 (0.44) | MAPK14MAPK11RIPK2BTKALDH1A1 | |
| SCHEMBL1417182 | 0.82 | MAPK14 (0.52) | MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298743-A1 | 5-membered heterocycle-based P38 kinase inhibitors | Novartis AG (CH) | 2011-03-23 | — | — | EP | claimed |