Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382984 | 0.90 | MAPK14 (0.53) | MAPK14MAPK11RIPK2AXLMERTK | |
| SCHEMBL1417180 | 0.82 | MAPK14 (0.56) | MAPK14MAPK11HPGD | |
| SCHEMBL1417048 | 0.82 | MAPK14 (0.47) | MAPK14MAPK11RIPK2BTKALDH1A1 | |
| SCHEMBL1417219 | 0.81 | HPGD (0.54) | MAPK14MAPK11RIPK2HPGD | |
| SCHEMBL1416992 | 0.81 | MAPK14 (0.49) | MAPK14MAPK11HPGDBTK | |
| SCHEMBL1417099 | 0.81 | MAPK14 (0.50) | MAPK14MAPK11HPGDBTK | |
| SCHEMBL1385955 | 0.80 | MAPK14 (0.51) | MAPK14MAPK11HPGD | |
| SCHEMBL1417233 | 0.79 | MAPK14 (0.50) | MAPK14MAPK11HPGD | |
| SCHEMBL1385285 | 0.79 | MAPK14 (0.54) | MAPK14MAPK11RIPK2ALDH1A1TSHR | |
| SCHEMBL12936145 | 0.78 | MAPK14 (0.53) | MAPK14MAPK11RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | Novartis AG (CH) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005009973-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-02-03 | — | — | WO | disclosed |