⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253538 | 0.74 | — | — | |
| SCHEMBL16114909 | 0.74 | — | — | |
| SCHEMBL14514233 | 0.74 | — | — | |
| SCHEMBL7827574 | 0.72 | — | — | |
| SCHEMBL11034713 | 0.72 | — | — | |
| Acrylic Acid SCHEMBL27728563 | 0.70 | — | — | |
| Acrylic Acid SCHEMBL25407941 | 0.69 | LMNA (0.43) | — | |
| SCHEMBL5090096 | 0.69 | MCL1 (0.36) | — | |
| SCHEMBL503938 | 0.69 | — | — | |
| Nitrogen SCHEMBL27994081 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134716-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
| US-9765078-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160185782-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2016-06-30 | — | — | US | disclosed |
| US-9102678-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20140046055-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8580838-B2 | 5-membered heterocycle-based p38 kinase inhibitors | NOVARTIS AG (CH) | 2013-11-12 | — | — | US | disclosed |
| US-20130172352-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-07-04 | — | — | US | disclosed |
| US-8410160-B2 | 5-membered heterocycle-based P38 kinase inhibitors | NOVARTIS AG (CH) | 2013-04-02 | — | — | US | disclosed |
| US-8399659-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120264801-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-10-18 | — | — | US | disclosed |
| CN-1057456-A | Prepare pyridine-2 by the dichloro-dialkyl maleate, the method for 3-dicarboxylic acid dialkyl esters and derivative thereof | AMERICAN CYANAMID CO (US) | 1992-01-01 | — | — | CN | disclosed |
| CN-1057455-A | Prepare pyridine-2 by dichloro succinate dialkyl ester, the method for 3-dicarboxylic acid dialkyl esters and derivative thereof | AMERICAN CYANAMID CO (US) | 1992-01-01 | — | — | CN | disclosed |
| US-4818668-A | CONTAINING PHENOLIC CYAN COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1989-04-04 | — | — | US | disclosed |
| US-4649103-A | Heat-developable light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1987-03-10 | — | — | US | disclosed |
| US-4594313-A | Containing hetero rings | FUJI PHOTO FILM CO., LTD. (JP) | 1986-06-10 | — | — | US | disclosed |
| US-4574115-A | MULTILAYER, METAL GRAINS | FUJI PHOTO FILM CO., LTD. (JP) | 1986-03-04 | — | — | US | disclosed |
| US-4397864-A | LOW TOXICITY | MITSUITOATSU CHEMICALS INC. (JP) | 1983-08-09 | — | — | US | disclosed |
| US-4287298-A | AND A POLYESTER COATED WITH A COPOLYMER MADE FROM VINYLIDINE CHLORIDE, AN ALKYL ACRYLATE AND AN ALLYL OR VINYL MONOMER | CIBA-GEIGY AG (CH) | 1981-09-01 | — | — | US | disclosed |
| US-4244988-A | Method of coating linear polyester with aqueous latex | CIBA-GEIGY AG (CH) | 1981-01-13 | — | — | US | disclosed |
| US-4167593-A | Method of subbing a polyester base | CIBA-GEIGY AG (CH) | 1979-09-11 | — | — | US | disclosed |