Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14174793 | 0.82 | CCR1 (0.41) | CCR1CCR5CCR8HDAC6CXCR4 | |
| SCHEMBL2224542 | 0.82 | KDM4E (0.40) | CCR1CCR5CCR8HDAC6CXCR4 | |
| SCHEMBL13577890 | 0.82 | CCR1 (0.44) | CHRNB2CHRNA4CCR1CCR5CCR8 | |
| SCHEMBL825227 | 0.80 | MAPT (0.42) | CCR1CCR5CCR8HDAC6CXCR4 | |
| SCHEMBL14665877 | 0.80 | HSD17B10 (0.44) | CCR1CCR5CCR8HDAC6CXCR4 | |
| SCHEMBL5027155 | 0.79 | CCR1 (0.46) | CCR1CCR5CCR8HDAC6CXCR4 | |
| SCHEMBL31645820 | 0.79 | CCR1 (0.46) | CCR1CCR5CCR8HDAC6CXCR4 | |
| SCHEMBL16215917 | 0.79 | GBA1 (0.55) | CHRNB2CHRNA4 | |
| SCHEMBL825256 | 0.78 | TDP1 (0.43) | CCR1CCR5CCR8HDAC6CXCR4 | |
| SCHEMBL17409825 | 0.78 | CXCR4 (0.36) | CCR1CCR5CCR8HDAC6CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384952-B2 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-06-10 | — | — | US | disclosed |
| US-7384952-B2 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-06-10 | — | — | US | disclosed |
| EP-1857459-A2 | Pyrazolopyrimidine compound and a process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 2007-11-21 | — | — | EP | disclosed |