SCHEMBL14175665

SCHEMBL14175665

COC(=O)[C@H](CCSC)NC(=O)c1cccc2cc(NC(=O)[C@H](N)CS)ccc12

nearest known ligand 0.84

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FNTA P49354 15/20 0.84
FNTB P49356 15/20 0.84
PGGT1B P53609 4/20 0.53
TDP1 Q9NUW8 1/20 0.53
KMT2A Q03164 1/20 0.49
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA9 Q16790 1/20 0.47
HPGD P15428 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8750233 0.91 FNTA (1.00) FNTAFNTBPGGT1BTDP1
SCHEMBL14169145 0.87 FNTA (0.80) FNTAFNTBPGGT1BTDP1
SCHEMBL29450593 0.86 FNTA (1.00) FNTAFNTBPGGT1BTDP1KMT2A
SCHEMBL25722631 0.81 FNTA (0.64) FNTAFNTBPGGT1BTDP1HPGD
SCHEMBL8750304 0.77 FNTA (1.00) FNTAFNTBPGGT1BTDP1
SCHEMBL16136603 0.71 FNTA (0.67) FNTAFNTBPGGT1BTDP1CA1
SCHEMBL8097481 0.71 FNTA (0.67) FNTAFNTBPGGT1BTDP1CA1
SCHEMBL8623007 0.71 FNTA (0.67) FNTAFNTBPGGT1BTDP1CA1
SCHEMBL10038916 0.71 FNTA (0.67) FNTAFNTBPGGT1BTDP1CA1
SCHEMBL8365606 0.69 FNTA (1.00) FNTAFNTBPGGT1BTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080153758-A1 Compounds Which Inhibits Protein Prenylation E.G. Geranylgeransferse or Farnesyltransferase Inhibitors for Treating Parkinson's Disease EXONHIT THERAPEUTICS SA (FR) 2008-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153758-A1 Compounds Which Inhibits Protein Prenylation E.G. Geranylgeransferse or Farnesyltransferase Inhibitors for Treating Parkinson's Disease FNTA, GGPS1, FNTB FNTA 1/4885FNTB 3/4885PGGT1B 126/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.