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SCHEMBL8750233

SCHEMBL8750233

CSCC[C@H](NC(=O)c1cccc2cc(NC(=O)[C@@H](N)CS)ccc12)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ FNTA P49354 16/20 1.00
▸ FNTB P49356 16/20 1.00
▸ PGGT1B P53609 10/20 0.64
▸ TDP1 Q9NUW8 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14175665 0.91 FNTA (0.84) FNTAFNTBPGGT1BTDP1
SCHEMBL14169145 0.89 FNTA (0.80) FNTAFNTBPGGT1BTDP1
SCHEMBL8750304 0.85 FNTA (1.00) FNTAFNTBPGGT1BTDP1
SCHEMBL16136603 0.80 FNTA (0.67) FNTAFNTBPGGT1BTDP1
SCHEMBL8097481 0.80 FNTA (0.67) FNTAFNTBPGGT1BTDP1
SCHEMBL8623007 0.80 FNTA (0.67) FNTAFNTBPGGT1BTDP1
SCHEMBL10038916 0.80 FNTA (0.67) FNTAFNTBPGGT1BTDP1
SCHEMBL2324069 0.78 FNTA (0.62) FNTAFNTB
SCHEMBL9828951 0.78 FNTA (0.62) FNTAFNTB
SCHEMBL8626782 0.77 FNTA (0.82) FNTAFNTBPGGT1BTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0764149-A1 NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-03-26 — — EP disclosed
WO-1995034535-A1 NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1995-12-21 — — WO disclosed