Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 16/20 | 0.66 |
| ▸ | F2 | P00734 | 7/20 | 0.66 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.58 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.58 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.58 |
| ▸ | F9 | P00740 | 2/20 | 0.57 |
| ▸ | PROC | P04070 | 2/20 | 0.57 |
| ▸ | KLK1 | P06870 | 1/20 | 0.57 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | CFH | P08603 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14176258 | 0.97 | F10 (0.62) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176275 | 0.94 | F10 (0.65) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176245 | 0.93 | F10 (0.67) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176237 | 0.92 | F10 (0.60) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176284 | 0.91 | F10 (0.74) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176250 | 0.91 | F10 (0.62) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176253 | 0.91 | F10 (0.64) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176268 | 0.89 | F10 (0.65) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176252 | 0.89 | F10 (0.64) | F10F2CARM1PRSS1PRSS2 | |
| SCHEMBL14176239 | 0.88 | F10 (0.70) | F10F2CARM1PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381732-B2 | Pyrazolobenzamides and derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381732-B2 | Pyrazolobenzamides and derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-03 | — | — | US | disclosed |