Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 16/20 | 0.74 |
| ▸ | F2 | P00734 | 8/20 | 0.74 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.65 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.65 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.65 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.65 |
| ▸ | PROC | P04070 | 3/20 | 0.64 |
| ▸ | F9 | P00740 | 2/20 | 0.64 |
| ▸ | KLK1 | P06870 | 1/20 | 0.64 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.63 |
| ▸ | CFH | P08603 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14176239 | 0.95 | F10 (0.70) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176216 | 0.94 | F10 (0.69) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176217 | 0.93 | F10 (0.67) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176246 | 0.91 | F10 (0.66) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5100150 | 0.91 | F10 (0.79) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176255 | 0.91 | F10 (0.67) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176248 | 0.91 | F10 (0.67) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176264 | 0.90 | F10 (0.69) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176267 | 0.90 | F10 (0.68) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176218 | 0.90 | F10 (0.66) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381732-B2 | Pyrazolobenzamides and derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381732-B2 | Pyrazolobenzamides and derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-03 | — | — | US | disclosed |