Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.80 |
| ▸ | F2 | P00734 | 10/20 | 0.80 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.65 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.65 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.65 |
| ▸ | PROC | P04070 | 4/20 | 0.64 |
| ▸ | F9 | P00740 | 3/20 | 0.64 |
| ▸ | KLK1 | P06870 | 1/20 | 0.64 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.63 |
| ▸ | CFH | P08603 | 1/20 | 0.63 |
| ▸ | PLAU | P00749 | 1/20 | 0.60 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.60 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100150 | 0.93 | F10 (0.79) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5097161 | 0.93 | F10 (0.79) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176284 | 0.89 | F10 (0.74) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176279 | 0.86 | F10 (0.71) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176262 | 0.86 | F10 (0.71) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176261 | 0.86 | F10 (0.70) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176239 | 0.86 | F10 (0.70) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176260 | 0.86 | F10 (0.70) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176273 | 0.86 | F10 (0.70) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14176259 | 0.85 | F10 (0.69) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381732-B2 | Pyrazolobenzamides and derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-7381732-B2 | Pyrazolobenzamides and derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-03 | — | — | US | disclosed |