Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814189 | 0.86 | TP53 (0.38) | CACNA2D1KMT2ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL14178889 | 0.86 | TP53 (0.38) | CACNA2D1KMT2ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL14178918 | 0.83 | CYP3A4 (0.40) | KMT2ASMN1; SMN2MAPK1ALDH1A1CYP2C9 | |
| SCHEMBL1892286 | 0.78 | MAPT (0.48) | KMT2AMAPK1ALDH1A1MEN1MAPT | |
| SCHEMBL1892283 | 0.78 | MAPT (0.48) | KMT2AMAPK1ALDH1A1MEN1MAPT | |
| SCHEMBL14178925 | 0.76 | CXCR3 (0.51) | CXCR3 | |
| SCHEMBL14178931 | 0.75 | CXCR3 (0.59) | CXCR3 | |
| SCHEMBL4810109 | 0.72 | TP53 (0.41) | KMT2ASMN1; SMN2MAPK1TP53ALDH1A1 | |
| SCHEMBL4810832 | 0.70 | CXCR3 (0.41) | KMT2ASMN1; SMN2MAPK1TP53ALDH1A1 | |
| SCHEMBL4810840 | 0.70 | CXCR3 (0.41) | KMT2ASMN1; SMN2MAPK1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375102-B2 | Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use | AMGEN SF, LLC (US) | 2008-05-20 | — | — | US | disclosed |