Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 16/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417778 | 0.97 | FBP1 (0.63) | FBP1EGFRERBB2ERBB4HDAC3 | |
| SCHEMBL1418205 | 0.93 | FBP1 (0.66) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL1417808 | 0.90 | FBP1 (0.68) | FBP1EGFRERBB2ERBB4 | |
| SCHEMBL7522202 | 0.90 | FBP1 (0.61) | FBP1EGFRERBB2ERBB4HDAC3 | |
| SCHEMBL1418998 | 0.90 | FBP1 (0.64) | FBP1EGFRERBB2ERBB4 | |
| SCHEMBL1417908 | 0.90 | FBP1 (0.67) | FBP1EGFRERBB2 | |
| SCHEMBL4234820 | 0.89 | KDR (0.60) | FBP1EGFRERBB2ERBB4HDAC3 | |
| SCHEMBL1418388 | 0.89 | EGFR (0.53) | FBP1EGFRERBB2ERBB4HDAC3 | |
| SCHEMBL4235071 | 0.89 | KDR (0.60) | FBP1EGFRERBB2ERBB4HDAC3 | |
| SCHEMBL4233765 | 0.88 | FBP1 (0.60) | FBP1EGFRERBB2ERBB4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |