Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.41 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838307 | 0.93 | HSP90AA1 (0.42) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4838315 | 0.93 | HSP90AA1 (0.42) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14181779 | 0.91 | NPC1 (0.42) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4846384 | 0.89 | SCD (0.38) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4846371 | 0.89 | SCD (0.38) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14181800 | 0.88 | MAPT (0.39) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4837771 | 0.86 | MAOA (0.47) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4837758 | 0.86 | MAOA (0.47) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4839812 | 0.86 | SNCA (0.39) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4839829 | 0.86 | SNCA (0.39) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378428-B2 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-27 | — | — | US | disclosed |