Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 19/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418228 | 1.00 | EGFR (0.72) | EGFRERBB2GAK | |
| SCHEMBL1419053 | 0.90 | EGFR (0.61) | EGFRERBB2GAK | |
| SCHEMBL1419055 | 0.90 | EGFR (0.61) | EGFRERBB2GAK | |
| SCHEMBL1417881 | 0.86 | EGFR (0.62) | EGFRERBB2GAK | |
| SCHEMBL1417882 | 0.86 | EGFR (0.62) | EGFRERBB2GAK | |
| SCHEMBL1418008 | 0.86 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL1418005 | 0.86 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL6382006 | 0.84 | EGFR (1.00) | EGFRERBB2GAK | |
| SCHEMBL6381499 | 0.82 | EGFR (0.83) | EGFRERBB2GAK | |
| SCHEMBL6381497 | 0.82 | EGFR (0.83) | EGFRERBB2GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |