Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | STK4 | Q13043 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419055 | 1.00 | EGFR (0.61) | EGFRERBB2BTKGAKSTK4 | |
| SCHEMBL1418229 | 0.90 | EGFR (0.72) | EGFRERBB2GAK | |
| SCHEMBL1418228 | 0.90 | EGFR (0.72) | EGFRERBB2GAK | |
| SCHEMBL1419083 | 0.87 | EGFR (0.65) | EGFRERBB2GAKSTK4 | |
| SCHEMBL1419084 | 0.87 | EGFR (0.65) | EGFRERBB2GAKSTK4 | |
| SCHEMBL6500373 | 0.87 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL1418433 | 0.87 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL1418422 | 0.82 | EGFR (0.67) | EGFRERBB2GAKSTK4 | |
| SCHEMBL1418420 | 0.82 | EGFR (0.67) | EGFRERBB2GAKSTK4 | |
| SCHEMBL1417887 | 0.82 | EGFR (0.68) | EGFRERBB2GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |