Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CD44 | P16070 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20439331 | 0.92 | CYP3A4 (0.31) | MAPK1CYP3A4TSHR | |
| SCHEMBL20109373 | 0.82 | CYP3A4 (0.48) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL19535201 | 0.80 | CYP3A4 (0.52) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL12181242 | 0.77 | CYP3A4 (0.37) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL21317778 | 0.75 | CYP3A4 (0.41) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL23041366 | 0.74 | CD44 (0.48) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL25648747 | 0.73 | GRIA1 (0.40) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL30476125 | 0.72 | CYP3A4 (0.60) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL272781 | 0.72 | CYP3A4 (0.60) | MAPK1CYP3A4TSHRCD44ALDH1A1 | |
| SCHEMBL24899747 | 0.71 | CYP3A4 (0.52) | MAPK1CYP3A4TSHRCD44ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |