SCHEMBL19535201

SCHEMBL19535201

Cc1cc(N)c(C=N)cc1N

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.52
TSHR P16473 2/20 0.52
MAPK1 P28482 2/20 0.52
ALDH1A1 P00352 4/20 0.43
CYP1A2 P05177 1/20 0.38
ALOX15 P16050 1/20 0.38
CASP7 P55210 1/20 0.38
HIF1A Q16665 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TERT O14746 1/20 0.37
TDP1 Q9NUW8 3/20 0.36
CASP1 P29466 1/20 0.36
CD44 P16070 1/20 0.36
UHRF1 Q96T88 1/20 0.33
ATAD2 Q6PL18 1/20 0.33
APAF1 O14727 1/20 0.32
POLB P06746 1/20 0.31
GAA P10253 1/20 0.31
GFER P55789 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20109373 0.88 CYP3A4 (0.48) CYP3A4TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL24899747 0.86 CYP3A4 (0.52) CYP3A4TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL21317778 0.85 CYP3A4 (0.41) CYP3A4TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL12181242 0.82 CYP3A4 (0.37) CYP3A4TSHRMAPK1ALDH1A1CD44
SCHEMBL14185482 0.80 MAPK1 (0.36) CYP3A4TSHRMAPK1ALDH1A1CD44
SCHEMBL20437528 0.80 CYP3A4 (0.36) CYP3A4TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL25648747 0.79 GRIA1 (0.40) CYP3A4TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL8444257 0.76 TSHR (0.52) CYP3A4TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL20439331 0.76 CYP3A4 (0.31) CYP3A4TSHRMAPK1
SCHEMBL33943 0.76 CYP3A4 (0.86) CYP3A4TSHRMAPK1ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3448848-B1 POLYMORPHIC FORM OF N-{6-(2-HYDROXYPROPAN-2-YL)-2-[2-(METHYLSULPHONYL)ETHYL]-2H-INDAZOL-5-YL}-6-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXAMIDE Bayer Pharma AG (DE) 2023-09-27 EP disclosed
WO-2017186689-A1 SYNTHESIS OF INDAZOLES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-11-02 WO disclosed
WO-2017186703-A1 POLYMORPHIC FORM OF N-{6-(2-HYDROXYPROPAN-2-YL)-2-[2-(METHYLSULPHONYL)ETHYL]-2H-INDAZOL-5-YL}-6-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXAMIDE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-11-02 WO disclosed