Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | DPP3 | Q9NY33 | 1/20 | 0.48 |
| ▸ | GNRHR | P30968 | 2/20 | 0.47 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | KISS1R | Q969F8 | 3/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185772 | 0.97 | PTGS1 (0.48) | PTGS1DPP3GNRHRABCC2OPRM1 | |
| SCHEMBL14185769 | 0.96 | PTGS1 (0.54) | PTGS1DPP3GNRHRABCC2OPRM1 | |
| SCHEMBL14185784 | 0.96 | PTGS1 (0.46) | PTGS1DPP3GNRHRABCC2OPRM1 | |
| SCHEMBL14185776 | 0.91 | OPRM1 (0.49) | PTGS1DPP3GNRHRABCC2OPRM1 | |
| SCHEMBL14185767 | 0.91 | DPP3 (0.44) | PTGS1DPP3GNRHROPRM1KISS1R | |
| SCHEMBL14185778 | 0.89 | TACR1 (0.43) | PTGS1DPP3GNRHROPRM1KISS1R | |
| SCHEMBL14185777 | 0.88 | PTGS1 (0.47) | PTGS1DPP3GNRHRABCC2OPRM1 | |
| SCHEMBL14185752 | 0.83 | KDM4E (0.47) | — | |
| SCHEMBL7132691 | 0.80 | OPRM1 (0.51) | OPRM1 | |
| SCHEMBL30309813 | 0.80 | CAPN1 (0.56) | PTGS1DPP3GNRHRABCC2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378397-B2 | TRH-degrading ectoenzyme inhibitors | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2008-05-27 | — | — | US | disclosed |
| US-7378397-B2 | TRH-degrading ectoenzyme inhibitors | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2008-05-27 | — | — | US | disclosed |