Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | CCR8 | P51685 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | QDPR | P09417 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL827860 | 0.85 | CCR1 (0.54) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL30997801 | 0.85 | CCR1 (0.54) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL24823772 | 0.82 | CCR1 (0.52) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL13805980 | 0.82 | CCR1 (0.50) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL13271138 | 0.82 | KDM4E (0.50) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL19906098 | 0.80 | KDM4E (0.53) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL17721316 | 0.80 | KDM4E (0.53) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL24316619 | 0.80 | KDM4E (0.53) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL24316513 | 0.80 | KDM4E (0.53) | CCR1CCR5CCR8CXCR4OPRM1 | |
| SCHEMBL19906099 | 0.80 | KDM4E (0.53) | CCR1CCR5CCR8CXCR4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119515-A1 | Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis | SCHERING CORPORATION | 2008-05-22 | — | — | US | disclosed |
| US-20080119515-A1 | Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis | SCHERING CORPORATION | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119515-A1 | Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis | MAP3K20, MAP3K1, MAP3K19 | CCR1 3462/4885CCR5 3154/4885CCR8 3786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.