Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418841 | 1.00 | EGFR (0.59) | EGFRERBB2HDAC3KDRHDAC4 | |
| SCHEMBL1418260 | 0.97 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL1418259 | 0.97 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL1418183 | 0.94 | EGFR (0.62) | EGFRERBB2HDAC3KDRHDAC4 | |
| SCHEMBL1418182 | 0.94 | EGFR (0.62) | EGFRERBB2HDAC3KDRHDAC4 | |
| SCHEMBL1418061 | 0.92 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL1418063 | 0.92 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL1418995 | 0.92 | EGFR (0.65) | EGFRERBB2KDR | |
| SCHEMBL1418997 | 0.92 | EGFR (0.65) | EGFRERBB2KDR | |
| SCHEMBL1417867 | 0.89 | EGFR (0.60) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |