Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055534 | 0.96 | P2RX7 (0.42) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL14334492 | 0.95 | P2RX7 (0.44) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL14173595 | 0.93 | KMT2A (0.38) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL1368840 | 0.86 | P2RX7 (0.40) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL19388519 | 0.85 | USP2 (0.37) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL6703818 | 0.85 | P2RX7 (0.35) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL16081548 | 0.84 | P2RX7 (0.39) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL10325787 | 0.83 | KMT2A (0.37) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL10326318 | 0.83 | KMT2A (0.37) | P2RX7KMT2AMEN1MAPK1CTSL | |
| SCHEMBL13877007 | 0.83 | TDP1 (0.40) | P2RX7KMT2AMEN1MAPK1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075172-A2 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |