Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197567 | 0.81 | CSF1R (0.64) | CSF1RCYP3A4CYP1A2MTNR1AMTNR1B | |
| SCHEMBL14196178 | 0.70 | CSF1R (0.49) | CSF1RCYP3A4CYP1A2CYP2C9KIT | |
| SCHEMBL14197870 | 0.69 | CSF1R (0.49) | CSF1RCYP3A4CYP1A2CYP2C9KIT | |
| SCHEMBL14198421 | 0.69 | CSF1R (0.56) | CSF1RCYP3A4CYP1A2MTNR1AMTNR1B | |
| SCHEMBL14196170 | 0.68 | CSF1R (0.48) | CSF1RCYP3A4CYP1A2CYP2C9KIT | |
| SCHEMBL14197568 | 0.68 | CYP2C19 (0.48) | CSF1RCYP3A4CYP1A2CYP2C9KIT | |
| SCHEMBL14196173 | 0.68 | CSF1R (0.61) | CSF1RCYP3A4CYP1A2CYP2C9KIT | |
| SCHEMBL14197363 | 0.66 | CYP3A4 (0.54) | CSF1RCYP3A4CYP1A2CYP2C9KIT | |
| SCHEMBL14198419 | 0.64 | CSF1R (0.61) | CSF1RCYP3A4KITKDRFLT3 | |
| SCHEMBL14194089 | 0.63 | CYP3A4 (0.47) | CSF1RCYP3A4CYP1A2MTNR1ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063888-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |