Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 13/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14194089 | 0.90 | CYP3A4 (0.47) | CYP3A4CYP2C19CYP2C9GPR84KIT | |
| SCHEMBL14196167 | 0.88 | CYP3A4 (0.54) | CYP3A4CYP2C19CYP2C9GPR84KIT | |
| SCHEMBL14198419 | 0.82 | CSF1R (0.61) | CYP3A4CYP2C19GPR84KITCSF1R | |
| SCHEMBL14194977 | 0.79 | CYP3A4 (0.45) | CYP3A4CYP2C19CYP2C9GPR84KIT | |
| SCHEMBL1267694 | 0.77 | CSF1R (0.68) | CYP3A4CYP2C19CYP2C9GPR84KIT | |
| SCHEMBL13976950 | 0.75 | GPR84 (0.45) | CYP3A4CYP2C19CYP2C9GPR84KIT | |
| SCHEMBL14196175 | 0.75 | CSF1R (0.51) | CYP3A4CYP2C19CYP2C9GPR84KIT | |
| SCHEMBL14197567 | 0.74 | CSF1R (0.64) | CYP3A4CYP2C19CYP2C9KITCSF1R | |
| SCHEMBL14194093 | 0.72 | CSF1R (0.56) | CYP3A4CYP2C19CYP2C9GPR84KIT | |
| SCHEMBL1267508 | 0.72 | CYP3A4 (0.63) | CYP3A4CYP2C19CYP2C9GPR84KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008064255-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |